Abstract # 1814 Systemic levels of IgE as a determinant of self-rated health in patients with asthma

Allergic asthma is a chronic inflammatory disorder with both local and systemic inflammation and is associated with elevated levels of IgE. Poor self-rated health has repeatedly been associated to inflammatory markers, but the nature of this relationship in states of chronic inflammatory disease in not known. Likewise, such findings largely rely on cross-sectional investigations. Here, we investigated the associations between self-rated health and levels of IgE over time in patients with asthma. Self-rated health and levels of IgE were assessed in 181 (87 women) non-smoking patients with allergic asthma aged 18–64 years in a one-year longitudinal study with two repeated measurements. All patients had a confirmed IgE sensitization to at least one airborne perennial allergen. Analyses of associations between repeated measurements were performed using mixed regression models and spearman’s correlations. Poor self-rated health was associated with higher levels of seasonal IgE ( p p p  = 0.04). In conclusion, systemic levels of IgE in response to seasonal-, food and perennial allergens is a possible determinant of self-rated health in individuals with asthma.