Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams

Pavel Kudrin,Vallo Varik,Sofia Raquel Alves Oliveira,Jelena Beljantseva,Teresa del Peso-Santos,Ievgen Dzhygyr,Dominik Rejman,Felipe Cava,Tanel Tenson,Vasili Hauryliuk

Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams

2017

Pavel Kudrin
Vallo Varik
Sofia Raquel Alves Oliveira
Jelena Beljantseva
Teresa del Peso-Santos
Ievgen Dzhygyr
Dominik Rejman
Felipe Cava
Tanel Tenson
Vasili Hauryliuk

The nucleotide (p) ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance, and virulence. During amino acid starvation, the Escherichia coli (p) ppGpp synthetase RelA is activat ...

Keywords:

Microbiology
Biology
Amino acid
Escherichia coli
PpGpp synthetase
Virulence
Nucleotide
Regulator
Antibiotics
Biochemistry
Microbial metabolism
Ribosome
Thiostrepton

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