Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade

Peter Miller,Christopher J. Gibson,Arnav Mehta,Adam S. Sperling,Dennie T. Frederick,Michael Manos,Benchun Miao,Nir Hacohen,F. Stephen Hodi,Genevieve M. Boland,Benjamin L. Ebert

Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade

2020

Peter Miller
Christopher J. Gibson
Arnav Mehta
Adam S. Sperling
Dennie T. Frederick
Michael Manos
Benchun Miao
Nir Hacohen
F. Stephen Hodi
Genevieve M. Boland
Benjamin L. Ebert

PURPOSEConventional cytotoxic therapies increase the risk of clonal hematopoiesis and select for TP53-mutant clones, which carry a high risk for transformation to therapy-related myelodysplastic ne...

Keywords:

Cancer research
Blockade
Biology
clonal hematopoiesis
Immune checkpoint
Cytotoxic T cell
Fitness landscape

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