Gross hematuria in sickle cell trait and sickle cell hemoglobin-C disease.

Summary 1.The occurrence of gross hematuria in five cases of sickle cell trait and three cases of sickle cell hemoglobin-C disease is reported. The investigation of these patients included electrophoretic and fetal hemoglobin studies. 2.Some of the previous cases of sickle cell trait reported with symptoms of crisis and/or hematuria might well have been sickle cell hemoglobin-C disease. The literature is reviewed in this connection. 3.The finding of hematuria with sickle cell trait in a significant number of patients is believed to indicate a significant relationship. 4.The singular susceptibility of the kidney to stress associated with sickle cell trait is offered as a possible etiologic mechanism for the vascular defects causing hematuria.