Association of HLA-A and -B alleles with syphilis in Shandong Han population
2011
Objective To investigate the association of HLA-A and -B alleles with syphilis in 5handong Han population. Methods The allele frequencies of HLA-A and -B were detected in 205 patients with syphilis and 5944 normal human controls by PCR-sequence specific oligouueleotide probe (PCR-SSOP) method. Results The patients with syphilis showed a higher frequency of HLA-A*02, B*15, B*40 alleles (all P 〈 0.01, Pc 〈 0.05) and a lower frequency of HLA-A*26 allele (P = 0.003, Pe = 0.039) than the normal human controls did. There was an increased frequency of HLA-B*15 and B*40 alleles in patients with symptomatic syphilis (both P 〈 0.01, Pc 〈 0.05 ), as well as an elevated frequency of HLA-A*02, 11, 29, B* 15 and 40 alleles (all P 〈 0.01, Pe 〈 0.05) and a decreased frequency of HLA-A*30 and 33 in patients with asymptomatie syphilis (P -= 0.002, 0.026, Pc = 0.001, 0.013 respectively), compared with the normal human controls. The frequency of HLA-A*30 allele was significantly higher in patients with symptomatic syphilis than in those with asymptomatie syphilis (P = 0.001, Pc = 0.013). Conclusions There seems to he an association between HLA-A*02, B*15 and B*40 alleles and syphilis, between HLA-A*30 allele and symptomic syphilis, and between HLA-A*02, 11 and 29 alleles and asymptomatic syphilis, in Shandong Han population.
Key words:
Syphilis; HLA antigens; Alleles
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