zearalenone on early pregnancy in swine
1982
SUMMARY A corn culture of Fusarium roseum was added to astandardcorn-soybeanswine gestation ration. Low, middle,and high dosage mixed feeds contained 7, 38, and 64 mg ofzearalenone/kg offeed (7, 38, and 64 ppm) and 0.5, 2.5, and4.5 mg ofdeoxynivalenol/kg, respectively. Control feed wasthe standard ration without added F roseum corn culture.Mature gilts were bred bynatural service and fed control or F roseum molded feed from 3 to 34 days after breeding.'Themain effect ofthe molded feed was an inhibition offetal development, with decreased numbers of fetuses present in treated animals at slaughter (38 to 43 days afterbreeding). Normal litters were present in 7 of 8 controlanimals, in 2 of4 gilts given the low-dosagefeed, in 1 of 4gilts given the medium dosage, and in 0 of4 given the highdosage feed, Corpora lutea were maintained in all treatedanimals, as evidenced by serum progesterone concentrations. Serum estradiol concentrations were decreased ingilts in the middle- and high-dosage groups. The genitalsystem of the gilts fed low- and middle-dosagefeeds had agross and microscopic appearance similar to that of thepregnant controls and reflected prolonged progesterone.stimulation. Morphologic changes in the genital system ofthe high-dosagegroup were intermediate between changesinduced by progesterone and those induced by estrogen,Clinical signs ofhyperestrogenism and partial feed refusalwere noticed in onlysome ofthehigh-dosagegroup animals,Zearalenone, a metaboliteof
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