Breaking the Silence: Brain-Computer-Interfaces in Paralysis (R & CA)

At Time 1, for both groups the Counting Stroop task was associated with significant activation in the left superior parietal lobule (SPL). No activation was noted in the anterior cingulate cortex (ACC). For the Go/NoGo task, in both groups, there was no significant activity in the prefrontal cortex (PFC) and striatum at Time 1. At Time 2, for both groups the Counting Stroop task was still associated with significant activation of the left SPL. This time, however, there was a significant activation of the right ACC, left caudate, and left substantia nigra in the EXP group. No such activation was seen in CON subjects. For the Go/NoGo task, significant loci of activation were noted, in the EXP group, in the lateral PFC, bilaterally, as well the left caudate nucleus, left thalamus, left substantia nigra, and right ACC. No significant activation of these brain regions was measured in CON subjects. Discussion These results suggest that NFT has the capacity to functionally normalize the brain systems mediating attention and response inhibition in AD/HD children. Given the pivotal role played by dopamine in these executive functions, we hypothesize that NFT modulates dopaminergic neurotransmission in fronto-striatal circuits.