Sex differences in angiotensin II responses contribute to a differential regulation of cox-mediated vascular dysfunction during aging.

Abstract Aging is a cardiovascular risk factor partially related to activation of the Renin-Angiotensin System (RAS). RAS activation is also influenced by sex. In this regard, our study aims to determine whether sex-associated differences in RAS contribute to a differential regulation of vascular aging and associated dysfunction. Male and female outbreed CD-1 mice were studied at 3 and 12 months of age (M). Contribution of RAS was determined by treating mice from 3 M to 12 M with the AngII type 1 receptor blocker losartan (0.6 g/L in the drinking water). At 12 M, contractions to AngII were higher in males compared to females ( P