Mieloma Múltiple: Métodos de Diagnóstico

Patellar instability is a common injury that Multiple myeloma (MM) is a neoplastic monoclonal proliferation of plasma cells, with more frequent affection to the bone marrow, and requires a number of diagnostic methods to know the staging, treatment and follow-up. It requires evidence of the existence in the blood or urine of the monoclonal protein (component M), by means of the quantification of serum immunoglobulins, protein electrophoresis, immunofixation, total protein in 24-hour urine, aspiration, and unilateral cytogenetic biopsy using fluorescence in situ hybridization (FISH). Other methods like bone scan are affected by low sensitivity. Tc-99m MIBI has been proposed in staging and follow-up, proton emission tomography (PET-FDG) has been proposed in MM for its ability to detect active metabolic disease throughout the body. Furthermore, a great scientific effort is being made to redefine the monitoring of the response of the treatment of multiple myeloma (MM), resulting in the development and validation of highly sensitive techniques to detect minimal residual disease (MRD), however questions remain unanswered about these methods other than the clinical evolution of the patient.