Farnesol sensitivity of serum induced yeast to hyphae morphogenesis: a study on fifty clinical isolates of Candida albicans.

ABSTRACT Aim: Objective of this study was to examine farnesol sensitivity of yeast to hyphaedimorphism in clinical isolates of Candida albicans.Study Design: Variations in virulence attributes contribute to variations in pathogenicity ofC. albicans. Ability to switch from yeast to hyphae morphology is an important virulencefactor. Farnesol, a quorum sensing molecule is known to play an important role in theregulation of C. albicans morphogenesis. Analysis of farnesol susceptibility of yeast tohyphae conversion may reveal a factor responsible for variation in pathogenicity amongclinical isolates of C. albicans.Place and Duration of Study: SCG Medical College & SGGS Memorial Hospital, andSchool of Life Sciences, SRTM University, Nanded, India. Duration of this study was,December 2008 to December 2010.Methodology: Fifty clinical isolates of C. albicans were recovered from body fluids (suchas, sputum, blood, urine, vaginal swab, tracheal swab, throat swab, feces, pus andcerebrospinal fluid, etc.) of patients with different clinical manifestations, in the tertiary careResearch Article