CASPASE CASPASE-3 biomarkers expression in esophageal epidermoid carcinoma -3 biomarkers expression in esophageal epidermoid carcinoma -3 biomarkers expression in esophageal epidermoid carcinoma -3 biomarkers expression in esophageal epidermoid carcinoma -3 biomarkers expression in esophageal epidermoid carcinoma

ABSTRACT Objectives: : : To analyze by cytophotometry study the expression of CD-34 angiogenesis and caspase-3 apoptosis markers in theesophagus squamous cell carcinoma and to correlate markers themselves. Methods: Twenty-nine esophageal squamous cellcarcinoma specimens were submitted to immunohystochemical analysis, based on label index of CD-34 and caspase-3 antibodies,using cytophotometry computer system. Variables considered in the correlation analysis were biomarkers expression quantification,patient age, lesion size, and TNM classification system. Results: Index label median value for CD-34 was 72,6% and for caspase-3 represented 96,5%. Statistical significant correlation was not demonstrated between the respective biomarkers and lesion size(p=0,96) or patient age (p=0,95). There was a slightly tendency to a positive correlation between CD-34 index label and TNMclassification system (p=0,11). Although presenting a higher index label than CD-34 marker (p=0,007), caspase-3 did not showany relationship with the studied variables (p>0,19). The correlation between CD-34 and caspase-3 presented a small positivetendency (r=0,09 and p=0,65). Conclusion: Both studied biomarkers showed good expression in esophageal squamous cellcarcinoma, whereas CD-34 marker presented lower expression than caspase-3 in this specific tumor. The respective biomarkersdo not demonstrate any correlation between themselves.Key words: Antigenos CD34. Cytophotometry. Carcinoma, squamous cell.€€€Esophageal neoplasms.