An Intramolecular Heck Approach To Obtain 17-Membered Macrocyclic Diversity and the Identification of an Antiangiogenesis Agent from a Zebrafish Assay

Madhu Aeluri,Jagan Gaddam,Devarakonda V. K. S. Trinath,Gayathri Chandrasekar,Satish Srinivas Kitambi,Prabhat Arya

An Intramolecular Heck Approach To Obtain 17-Membered Macrocyclic Diversity and the Identification of an Antiangiogenesis Agent from a Zebrafish Assay

2013

Madhu Aeluri
Jagan Gaddam
Devarakonda V. K. S. Trinath
Gayathri Chandrasekar
Satish Srinivas Kitambi
Prabhat Arya

We report a practical and modular approach to obtain two different types of 17-membered ring macrocyclic compounds through an intramolecular Heck reaction. These macrocyclic compounds are functiona ...

Keywords:

Chemistry
Combinatorial chemistry
Small molecule
Organic chemistry
Intramolecular force
Heck reaction
c c coupling
Stereochemistry
Zebrafish

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