Evaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead

The growing prevalence of antibiotic-resistant pathogens continues to drive the need for antibiotics with novel modes of action. Of particular concern are infections caused by multidrug- resistant Mycobacterium tuberculosis, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), penicillin-resistant Streptococcus pneumoniae, fluoroquinolone-resistant Pseudomonas aeruginosa (FQRP), and β-lactam-resistant Gram-negative organisms, since many of these pathogens are intransigent to multiple classes of drugs.[1–3] Among discovery strategies, the empirical screening of chemical entities that are structurally distinct from clinically established agents represents an effective approach to developing novel antibiotics.