Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection

Abstract Electrophysiological recording demonstrated that visuo-tectal projections are topographically organised after optic nerve regeneration in aged Xenopus laevis . 3 H-thymidine autoradiography confirmed previous reports [Taylor, Lack, & Easter, Eur. Journal of Neuroscience 1 (1989) 626–638] that cell division had already ceased at the retinal ciliary margin. The results demonstrate that, contrary to a previous suggestion [Holder & Clarke, Trends in Neuroscience 11 (1988) 94–99], continued neurogenesis is not a pre-requisite for the re-establishment of appropriate connections with target cells.