Design of a hyperstable 60-subunit protein icosahedron

Yang Hsia,Jacob B. Bale,Shane Gonen,D. Shi,William Sheffler,Kimberly K. Fong,Una Nattermann,Chunfu Xu,Po-Ssu Huang,Rashmi Ravichandran,Sue Yi,Trisha N. Davis,Tamir Gonen,Neil P. King,David Baker

Design of a hyperstable 60-subunit protein icosahedron

2016

Yang Hsia
Jacob B. Bale
Shane Gonen
D. Shi
William Sheffler
Kimberly K. Fong
Una Nattermann
Chunfu Xu
Po-Ssu Huang
Rashmi Ravichandran
Sue Yi
Trisha N. Davis
Tamir Gonen
Neil P. King
David Baker

The computational design of an extremely stable icosahedral self-assembling protein nanocage is presented; the icosahedron should be useful for applications ranging from calibrating fluorescence microscopy to drug delivery.

Keywords:

Ranging
Fluorescence microscope
Icosahedral symmetry
Crystallography
Protein subunit
Protein design
Chemistry
Icosahedron
Protein structure
Nanocages
Pentamer
Nanotechnology
Materials science
Population

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