15-year clinical experience in ATG induction after renal transplantation

Objective To summarize the experience of ATG induction combined with standard irnmunosuppression in order to prolong the long-term survival of patient/kidney after renal transplantation.Method The data of renal transplantation in 1632 cases who received renal transplantation from Jan.1997 to Jan.2012 were summarized.The data of the recipients were calculated,such as the 1-,3-,5-,10-and 15-year survival rate of patient/graft,and other factors affecting transplantation outcomes.Results The 1-,3-,5-,10-and 15-year survival rate of patient/graft (％) was 97.0/96.7,93.2/87.8,88.2/77.8,78.5/51.7,and 40.2/30.4 respectively.The incidence of acute rejection (AR) was 9.1％ (149 cases).The incidence of delayed graft function (DGF) was 7.7％ (126 cases).The incidence of chronic graft dysfunction was 17.9％ (292 cases).The incidence of infection and cancer after transplantation was 13.4％ (219 cases) and 1.2％ (19cases) respectively.Mortality of recipients after transplantation was 7.6％ (124 cases).Among the 173 dead cases,53.2％ (66 cases) was caused by infections,33.9％ (42 cases) by cardiovascular complication,and 8.9％ (11 cases) by cancer,respectively.Conclusion The regimen of ATG induction therapy combined with standard triple immunosuppressive therapy can prevent acute rejection effectively in the early period after renal transplantation.It is an effective treatment to improve long-term patient/graft survival. Key words: Kidney transplantation;  ATG;  Induction therapy;  Survival rate