Off-label and unlicensed drug treatments in Neonatal Intensive Care Units: an Italian multicentre study

Purpose The use of medicines among newborns admitted to intensive care units is characterized by a high prevalence of off-label/unlicensed use and a wide variability in the absence of international guidelines. A prospective cross-sectional study was organized with the aim to analyse drug prescriptions among all 107 Italian level III neonatal intensive care units.