Novel nanostructured MIL-101(Cr)/XC-72 modified electrode sensor: A highly sensitive and selective determination of chloramphenicol

Abstract A novel MIL-101(Cr)/XC-72 modified glassy carbon electrode (GCE) sensor was fabricated to determine chloramphenicol (CAP). The electrochemical sensors were constructed by using MIL-101(Cr), XC-72, MIL-101(Cr)/XC-72, and their electrochemical performances were studied with cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. In comparison with the GCE, MIL-101(Cr)/GCE and XC-72/GCE sensors, the MIL-101(Cr)/XC-72/GCE sensor exhibited a well-defined redox peak towards CAP in phosphate buffer solution (PBS). The effects of the ratio of MIL-101(Cr) and XC-72, accumulation time, scan rate, and pH value were carefully considered. Under the optimized conditions, the sensor exhibited excellent response for CAP. The linear concentration ranges of CAP were from 1.0 × 10 −8 to 2.0 × 10 −5  M (R 2  = 0.985), with a low detection limit of 1.5 × 10 −9  M (S/N = 3). Furthermore, the MIL-101(Cr)/XC-72/GCE sensor was successfully applied to the determination of the real samples with satisfactory recoveries.