Chlorquinaldol-promestriene vaginal emulsifiable micro-emulsion soft capsule and preparation method thereof

The invention relates to a chlorquinaldol-promestriene vaginal emulsifiable micro-emulsion soft capsule and a preparation method thereof. The chlorquinaldol promestriene vaginal emulsifiable micro-emulsion soft capsule is a vaginal soft capsule which has favorable dissolution time and does not have local stimulation. In the invention, chlorquinaldol, promestriene, oil phase, a surfactant and a cosurfactant form a uniform transparent solution which is a micro emulsion with grain size less than 100nm. The preparation method comprises the steps of: heating to dissolve the surfactant, the cosurfactant and the oil phase under a temperature of 10-80DEG C, mixing sufficiently and evenly, adding the chlorquinaldol and the promestriene, mixing at the room temperature to dissolve the drugs so as toobtain a transparent solution, and filling to obtain the soft capsule. In the invention, a stable chlorquinaldol-promestriene micro emulsion can be obtained; by micronizing the chlorquinaldol and thepromestriene, the biologic utilization degree of the main drugs can be improved, the effect is rapid and the defect of lower biologic utilization degree of common vaginal sheets is overcome; at the same time, as a new combined form, the soft capsule can provide a newer and better form selection for the doctors and the patients.