Functional-Protein-Assisted Fabrication of Fe–Gallic Acid Coordination Polymer Nanonetworks for Localized Photothermal Therapy

Fe-polyphenols coordination polymers have emerged as a versatile theranostic nanoplatform for biological applications owing to the appealing biocompatibility of precursors from nature. Incorporating bioactive molecules with Fe-polyphenols coordination polymers is greatly significant to take full advantages of their superiorities for advanced application. Herein, we show functional protein-assisted fabrication of Fe-gallic acid (GA) nanonetworks via a mild and facile biomineralization for photothermal therapy. Mild alkaline condition is crucial to obtain protein-Fe-GA nanonetworks with intense near-infrared absorption and their unique network structure allows reducing the leakage to the surrounding normal tissues, benefiting high photothermal therapeutic efficacy and minimal side effects. The proposed bovine serum albumin-Fe-GA nanonetworks are successfully used to eradicate tumor in vivo. In addition, this universal method can be extended to synthesize other protein-involved nanonetworks, such as human se...