Synthesis of New L-Ascorbic Ferulic Acid Hybrids

Abstract: A feasibility and chemical study of the coupling conditions of L -ascorbic acid with ferulic acid derivatives are described on the basis of the known synergistic effects of mixtures of various antioxidants. Novel L -ascorbic ferulic hybrids linked at the C-3 hydroxyl group were prepared with the aim to protect the alcohol function and the enediol system. Keywords: Ascorbic acid, ferulic acid, hybridization, antioxidant, oxidative stress. Introduction Oxidative stress is thought to play an important contributory role in the pathogenesis of numerous degenerative or chronic diseases, such as cancer. Besides, experimental evidence links the production of reactive oxygen species to biological damage that can potentially provide a mechanistic basis for their initiation and/or progression. For this reason we were especially interested in the use of antioxidants in this context of photoprotection and we have already developed a synthesis program that was aimed at the preparation of antioxidant trans-1,2-diarylethenes from cinnamic acids [1].