Chronic Blood Vessel Catheterization in Gottingen Miniature Pigs and Application to a Preliminary Bioavailability Study of Nalidixic Acid

A surgical procedure for chronic jugular vein cannulation of Gottingen miniature pig for repeated blood samplings is described. Cannulated minipigs G were used for a preliminary study of the bioavailabilities of nalidixic acid tablets showing different dissolution rates and to investigate the elimination profiles of nalidixic acid in blood after intravenous administration of the drug. The results indicate the usefulness of these catheterized minipigs G for bioavailability studies requiring fequent blood samplings.