Валидация систем преимплантационного тестирования моногенных заболеваний на единичных клетках и продуктах полногеномной амплификации

Pre-examination single cell validation was performed for preimplantation genetic testing (PGT-M) for 9 monogenic disorders by nested PCR for STR and pathogenic variants. Totally 109 single cells and 24 WGA products (by MDA) were analyzed.