Crosstalk between ER-stress and apoptosis in irradiated HepG2 cells with gemcitabine: implication of PI3K/AKT and IκB/NF-κB signaling pathways

ABSTRACTGemcitabine (GEM) is an anti-cancer drug that has been used in the treatment of a wide range of human cancers. However, cancer cells developing resistance to GEM which may limit its use. So...