ИММУНОЛОГИЧЕСКИЕ КОРРЕЛЯТЫ КАНДИДАТНОЙ ДНК-ВАКЦИНЫ ПРОТИВ ВИЧ-1 СУБТИПА А

Since 1981, when AIDS was identified as a disease about 60 million of HIV infected people have been registered and 30 million have died according to WHO. The development of vaccines against HIV/AIDS is an important step in solving this problem. In the absence of an adequate animal model for HIV, vaccine development requires an understanding of immunological correlates of HIV protection. In this study we investigated the immunological correlates of a candidate HIV-1 DNA vaccine. We analyzed the specific immune responses in phase I clinical trial participants and in HIV exposed seronegative individuals. In both groups, an increase in TNFα cytokine by CD4+ T cells in response to specific peptide stimulation was found. This could be an indicator of the possible vaccine efficacy.