Effect of Jinshuibao plus benazepril on proteinuria in patients with diabetic nephropathy.

OBJECTIVE: To investigate the effect of Jinshuibao plus benazepril on proteinuria in patients with diabetic nephropathy. METHODS: 100 patients with diabetic nephropathy admitted to Guangzhou Panyu District Hexian Memorial Hospital from June 2011-May 2013 were randomly assigned to either control group treated with benazepril alone orobservation group treated with Jinshuibao plus benazepril. The 24-hour urine protein,urine microalbumin excretion rate,serum creatinine and urea nitrogen levels before and after treatment were compared between the two groups,meanwhile,the adverse drug reactions and patients' satisfaction degree to treatment were evaluated. RESULTS: After treatment,the 24-hour urine protein,urine microalbumin excretion rate,serum creatinine and urea nitrogen levels decreased in both groups,much as in the observation group,and the difference was statistically significant between the two groups( P 0. 05); after treatment,no significant change was noted in urea nitrogen level in both groups and the difference between the two groups were insignificant( P 0. 05); neither group showed serious adverse drug reaction( ADR),and the ADR occurred slightly yet insignificantly less frequent in the observation group than in the control group; the rate of patients who were satisfied toward treatment in observation group was significantly higher than in the control group( 96. 0% vs. 72. 0%),and the difference was statistically significant( P 0. 05). CONCLUSION: Addition of Jinshuibao to benazepril in treatment of patients with diabetes resulted in significant improvement in urinary protein level and patients' satisfaction to treatment,and the two drugs showed complementary effect yet without causing serious adverse drug reaction,hence this combination therapy is worthy of clinical recommendation.