Nanowell Array based Sensor and Its Packaging

Department of Congo-Mechatronics Engineering, Pusan National University, Busan 609-735, Korea(Received September 5, 2014: Corrected September 18, 2014: Accepted September 19, 2014)Abstract: This article reviews the recent progress in nanowell array biosensors that use the label-free detection protocol,and are detected in their natural forms. These nanowell array biosensors are fabricated by nanofabrication technologiesthat should be useful for developing highly sensitive and selective also reproducible biosensors. Moreover, electrochemicalmethod was selected as analysis method that has high sensitivity compared with other analysis. Finally, highly sensitivenanobiosensor was achieved by combining nanofabrication technologies and classical electrochemical method. Manyexamples are mentioned about the sensing performance of nanowell array biosensors will be evaluated in terms ofsensitivity and detection limit compared with other micro-sized electrode without nanowell array.Keywords: Nanowell Arrays (NWA), Nanobiosensor, Electrochemical (EC) method, Chip-packaging