Expression of Bag-1 and Bcl-2 and its significance in gastric cancer

AIM: To investigate the expression of Bag-1 and Bcl-2 protein and its clinical significance in gastric cancer (GC). METHODS: Immunohistochemistry was used to detect the expressison of Bag-1 and Bcl-2 protein in 92 patients with gastric cancer and 40 normal tissues as control. RESULTS: Compared with normal mucosa, Bag-1 and Bcl- 2 were over-expressed in gastric cancerous tissues (60.9% vs 7.5%, 72.8% vs 10%, P<0.01). The expression of Bcl-2 protein was significantly correlated with the differentiation degree (rs = 0.513, P<0.05) and the expression of Bag-1 was significantly associated with Bcl-2 level in gastric cancer (rs = 0.522, P<0.01). CONCLUSION: The over-expression of Bcl-2 leads to un- controlled growth and unceasingly increases of GC cells by accelerating cell transformation and proliferation. Bag- 1 promotes the function of Bcl-2 and co-expression of Bag- 1 and Bcl-2 may mean poor prognosis of GC patients.