Early warning factors of severe patients with COVID-19/ 重症新型冠状病毒肺炎患者早期预警因素的分析

Objective To investigate the early warning factors of severe patients with COVID-19 Methods A retrospective analysis was conducted on 73 patients with common COVID-19 admitted in Eighth People′s Hospital of Guangzhou from January to March 2020 According to disease progression during hospitalization, patients were divided into severe group (group A) and common group (group B) Admission lymphocytes, C reactive protein, serum amyloid protein A, lactic acid, eosinophils, lactate dehydrogenase, viral load, incidence time and relative extreme value (highest or lowest value) in the two groups were compared The clinical value of these indicators during disease progression was assessed Results LYM and EOS in group A were lower than those in group B (P<0 05) During hospitalization, the extreme values of LYM and EOS in A group were significantly lower than those in group B (all P<0 001) There was no significant difference between group A and group B in terms of initial LAC, while during hospitalization, the extreme values of LAC in group A were significantly higher than those in group B (all P<0 001) Initial CRP, SAA and LDH in group A were higher than those in group B (all P<0 05) but during hospitalization, the extreme values of CRP, SAA and LDH in group A were significantly higher than those in group B (all P<0 001) There was no difference in positive rate of coronavirus nucleic acid between group A and B on admission but it was higher in group A than that in B group during hospitalization (P=0 03) There was no statistical significance pertaining to time from onset to visiting the doctor and the median time of conversion to severe or critical cases was (10 03±3 96) days Conclusion LYM, CRP, SAA, LAC, EOS and LDH have significant differences in the conversion from common to severe and critical patients, and the change trend can be used as early warning indicators for severe and critical cases