Cerebrospinal fluid apolipoprotein E and phospholipid transfer protein activity are reduced in multiple sclerosis; relationships with the brain MRI and CSF lipid variables

Abstract Apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, lipids, total tau and beta amyloid 1-42 (Aβ 42 ) were measured in cerebrospinal fluid (CSF) from controls ( n =38) and multiple sclerosis (MS) patients ( n =91). ApoE and PLTP activity were significantly reduced in MS compared to non-inflammatory disease controls (NINDC; p r s =0.399 and 0.591, respectively), Aβ 42 ( r s =0.609 and 0.483, respectively), and total tau ( r s =0.748 and 0.380, respectively; all p p p