Childhood Trauma and Risk for Chronic Fatigue Syndrome

Childhood trauma appears to be a potent riskfactorforchronicfatiguesyndrome(CFS).Evidencefromdevelopmental neuroscience suggests that early experi-enceprogramsthedevelopmentofregulatorysystemsthatare implicated in the pathophysiology of CFS, includingthe hypothalamic-pituitary-adrenal axis. However, thecontributionofchildhoodtraumatoneuroendocrinedys-function in CFS remains obscure.