Diabetic cardiomyopathy in medical examination patients with impaired glucose tolerance and Type 2 diabetes

Objective: To investigate the change of diabetic cardiomyopathy in patients with impaired glucose tolerance(IGT) and Type 2 diabetes(T2DM) and its influencing factors. Methods: Patients with IGT and T2 DM were divided into an IGT group(n=314), a T2 DM group (n=368) and an NC group(400 normal subjects). The left ventricular ejection fractions(LVEF) and the interventricular septal depth(IVSd) were measured by Doppler echocardiography. The general information and blood biochemistry were also collected during the corresponding time period. Results: Compared with the NC group, waist circumference(WC), bodymass index(BMI), premature family history of cardiovascular disease, the serum levels of fasting plasma glucose(FPG), HbA1 c, TC, TG, hyperlipidemia, BUN and Cr significantly increased(P0.01) in the IGT and T2 DM groups. Compared with the NC group and the IGT group, the LVEF significantly decreased(P0.01) and the IVSd significantly increased(P0.01) in the T2 DM group. The LVEF and IVSd did not have obvious difference between the NC group and the IGT group. Pearson correlation analysis showed a negative correlation between LVEF and HbA1 c, TC and duration of disease(P0.01); but a positive correlation between IVSd and WC, BMI, HbA1 c and duration of disease, and a negative correlation between IVSd and HDL(P0.05). In the multiple linear stepwise regression, HbA1 c and duration of disease showed a significant association with both LVEF and IVSd(P0.05).Conclusion: T2 DM has a close association with cardiomyopathy. HbA1 c and duration of disease are the independent predictors for LVEF and IVSd.