Abstract 11965: Novel Simple and Accurate Quantitative Endothelial Function Measurements Using Brachial Artery Vascular Volume Elastic Modulus With Automated Oscillometric Approach

Background: Simple and automated arterial endothelial function measurements are desirable for atherosclerosis risk assessments. Vascular elastic modulus (VE) is uninfluenced by blood pressure and potentially is linked to endothelial function. However, previous VE measurements have been complex or invasive. Recently, we developed a novel modality of automated oscillometric method to measure a brachial artery’s VE. We aimed to investigate whether VE reflected endothelial dysfunction related to chronic kidney disease (CKD). We also evaluated the reliability of new automated VE methods. Methods: 13 moderate-to-severe CKD pts (mean estimated glomerular filtration rate [eGFR] 29.3±25.7 mL/min/1.73m2) and 16 controls were studied. Rest VE and estimated arterial cross sectional area (eA) in brachial artery were measured by new automated oscillometric detector. eA was estimated using pressure-volume curves and VE was defined as follows [VE = ΔPressure/ (100XΔarea / Area) mmHg/%]. Controls repeated eA and VE measur...