Methylprednisolone acetate injectable preparation from the microemulsion and

The present invention relates to a method for its preparation SMEDDS with one injection of methylprednisolone acetate. Methylprednisolone acetate injectable present invention SMEDDS, comprising the following weight percentage constituents: 0.5% -2.5% of methylprednisolone acetate, 1% to 40% of cosurfactant, 40% to 90% surfactant and 5% to 35% of an oil phase; the mass percentage of the above-described components were mixed mix was stirred until clear and then 0.05-0.1 wt% of activated carbon, adsorption of 40 deg.] C to reflux 30-60 min, then treated with 0.22μm filter membrane sterilization, aseptic filling, to obtain methylprednisolone acetate injectable use SMEDDS. Shortly before use methylprednisolone acetate injectable SMEDDS added to 0.9% NaCl saline, or 5% glucose injection microemulsion is formed. The present invention is obtained methylprednisolone acetate injectable formulation from transparent clear stable microemulsion, self-emulsifying high efficiency, simple preparation method, stable product quality, safety and reliability.