Major cardiovascular diseases: impacts of genetic and environmental factors and prospective for prevention and control

Cardiovascular disease (CVD) has been the leading cause of death and burden of diseases globally. In China, coronary artery disease and stroke have caused tremendous socioeconomic and disease burdens. The cardiovascular disease is influenced by both genetic and environmental factors. The genetic factors influencing cardiovascular disease, blood pressure and lipids have been identified by international and Chinese genomic studies, which provided foundation for the integration of multi-omics data, precision medicine as well as personalized prevention and treatment of CVD. In addition, based on large-scale cohorts and intervention studies, the major cardiovascular risk factors were also identified in China and worldwide. Furthermore, the 10-year and lifetime risk prediction models for atherosclerotic cardiovascular disease have been developed using our cohort data, which was more appropriate to Chinese populations. Following the implementation of the Strategy for Healthy China 2030, we will embrace unprecedented opportunities for CVD prevention and control. The supports from the government, the development of mobile health, and innovations from academic studies will facilitate our work on CVD prevention and treatment, and will be helpful to improve health among Chinese population.