Cell-type–based model explaining coexpression patterns of genes in the brain

Neuroanatomy is experiencing a renaissance due to the study of gene-expression data covering the entire mouse brain and the entire genome that have been recently released (the Allen Atlas). On the other hand, some cell types extracted from the mouse brain have been characterized by their genetic activity. However, given a cell type, it is not known in which brain regions it can be found. We propose a computational model using the Allen Atlas to solve this problem, thus estimating previously unidentified cell-type–specific maps of the mouse brain. The model can be used to define brain regions through genetic data.