Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

Nicoletta Sorvillo,Daniella M. Mizurini,Carmen H. Coxon,Kimberly Martinod,Ronak Tilvawala,Deya Cherpokova,Ari J. Salinger,Robert J. Seward,Caleb Staudinger,Eranthie Weerapana,Nathan I. Shapiro,Catherine E. Costello,Paul R. Thompson,Denisa D. Wagner

Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

2019

Nicoletta Sorvillo
Daniella M. Mizurini
Carmen H. Coxon
Kimberly Martinod
Ronak Tilvawala
Deya Cherpokova
Ari J. Salinger
Robert J. Seward
Caleb Staudinger
Eranthie Weerapana
Nathan I. Shapiro
Catherine E. Costello
Paul R. Thompson
Denisa D. Wagner

Rationale: Peptidylarginine deiminase type IV (PAD4), an enzyme essential for NET formation (NETosis), is released together with neutrophil extracellular traps (NETs) into the extracellular milieu....

Keywords:

Cardiology
Diabetes mellitus
Peptidylarginine Deiminase IV
Endocrinology
Biology
Thrombosis
Internal medicine
Platelet
Enzyme
Von Willebrand factor
Citrullination
Molecular biology
Neutrophil extracellular traps
Histone

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