Antibody-modified conduits for extracorporeal selectivecytokine filtration in sepsis; AMCs for extracorporeal selective cytokine filtrationin sepsis
2016
Sepsis kills millions of people worldwide each year
and occurs when microorganisms enter the bloodstream of an infected
host. The presence of microorganisms in the bloodstream triggers
the body to produce many inflammatory proteins, known as cytokines,
that cause damage to blood vessels and vital organs. This leads to
capillary leak, failing organs, and often death. We have developed
a novel approach to modulate the inflammatory response, using
antibody-modified conduits (AMCs) to filter harmful cytokines
selectively from the circulation and in a time-specific manner.
Here, we characterize variables that affect AMC performance to
determine optimal AMC conditions for later use
downstream.
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