Состояние микробиоты у пациенток с привычным невынашиванием беременности

Recurrent pregnancy loss is an acute social problem. The continuing high frequency of unspecified causes leads to the search for new possible risk factors to prevent pregnancy complications. One of them can be considered disorders of microbiocenosis of the gastrointestinal tract, especially in the presence of somatic diseases. A survey of 53 women with recurrent pregnancy loss in history. Gastroenterological pathology, such as chronic gastritis, gastroesophageal reflux disease, chronic non-calculous cholecystitis, irritable bowel syndrome, has been established that risk factors for recurrent pregnancy loss are. It is shown that the microbial-tissue complex of the gastrointestinal tract has a significant impact on changes in the qualitative and quantitative composition of the microbiota of the reproductive tract. The intestinal microbiota in women with recurrent pregnancy loss was characterized by excessive growth of conditionally pathogenic flora against the background of deficiency of lactobacilli and bifidobacteria and was closely associated with the formation of chronic genital pathology: salpingitis and endometritis, which are risk factors for the development of conditionally pathogenic flora. In turn, in the uterus in women with recurrent pregnancy loss, there was an increase in conditionally pathogenic flora against the background of an excess of Lactobacillus and Bifidobacterium and the presence of certain microbiota species in the uterine cavity was significantly correlated with similar species in the intestine. With the correction of disorders of the intestinal microbiota and the genital tract with the inclusion of a prebiotic complex, the uterine microbial landscape was significantly improved in the direction of normocenosis. This shows the possibility of using prebiotics for the correction of risk factors and reducing the development of recurrent pregnancy loss.