Molecular construction of multitarget neuroprotectors 1. Synthesis and biological activity of conjugates of substituted indoles and bis(dimethylamino)phenothiazine
2015
Synthetic strategy to access new multitarget neuroprotectors by conjugation of pharma-cophoric indole and bis(dimethylamino)phenothiazine moieties via 1-oxopropylene spacer was developed. The transformation was achieved by the cesium fluoride-catalyzed reaction of cycloalkaneindoles with 1-propenone. Effect of the synthesized compounds on neuronal NMDA receptors was evaluated by radioligand binding assay.
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