BREAST CANCER: PROGNOSTIC EVALUATION PERSPECTIVES BY TRANSCRIPTION FACTORS USING HISTOCHEMICAL IMMUNOLOCALIZERS AND FUNCTIONAL GENOMICS.

Breast Cancer: Prognostic Evaluation Perspectives by Transcription Factors Using Histochemical Immunolocalizers and Functional Genomics. Abstract The molecular characteristics of breast carcinomas have provided information on their behavior and have allowed the establishment of more effective strategies for their treatment. Transcription factors have been the target of study in neoplasms because they act in the modulation of genes that encode oncogenic proteins or tumor suppressors. In this broader context, the SOX transcription factors have been appreciated as potential prognostic and survival markers, as they are included in the list of emerging tumor biomarkers for breast cancer. Studies involving genes and proteins of the SOX family in breast cancer may provide important clues for the pathophysiology, diagnosis, and treatment of the disease.