The Relationship Between Serum Level of Vitamin D3 and Osseointegration Around the Dental Implant.

At present, dental implants are used more than before, and their high success rate is attributed to sufficient osseointegration, which, per se, depends on prosthetic, implant, and patient-related factors. The quality and quantity of bone and the host response are the main patient-related factors. Vitamin D3 affects the bone metabolism by stimulating both osteoclasts and osteoblasts. This study aimed to review the human studies on the efficacy of vitamin D3 for dental implant osseointegration. Search of the literature yielded only four studies on human models; out of which, two showed the optimal efficacy of vitamin D3 for dental implant osseointegration while the remaining two did not report any positive effect. However, this finding may be related to the small sample size of vitamin D3-deficient group, which can compromise statistical analyses. In conclusion, vitamin D3 seems to be effective for dental implant osseointegration, although further research is required on human models.