Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy
2016
Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic therapies.
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