Correlation between expression of the MTA1 gene and carcinomas of larynx

Objective:To study the relation between Mta1 gene(metastasis associated gene,meta gene)and lymph node metastasis of laryngeal carcinomas .Method:Reverse transcription polymeras chain reaction(RT-PCR) technique was used to detect the expression of Mta1 mRNA in 30 carcinoma of larynx tissue cases,12 lymph nodes and 10 normal larynx tissue cases.Result:The frequency of MTA1 overexpression was 100%(8/8) in primary carcinomas of larynx with metastasis but only 22.7%(5/22) in thoes without metastasis(P0.01).Expression of MTA1 was 87.5%(7/8) in lymph nodes with metastasis but only 0(0/4) in thoes without metastasis(P0.05). The frequency of Mta1 overexpression was 43.3 %( 13/30) in primary carcinomas of larynx.Conclusion:Our data suggest that the overexpression of the MTA1 gene correlates with lymph node metastasis of carcinomas of larynx.Mta1 gene will probably become a valuable gene for judging metastasis of laryngeal carcinoma.