Serum SIOOB protein and GFAP levels and their clinical significance in patients with delayed encephalopa- thy after acute carbon monoxide poisoning

Objective To explore the dynamic changes of serum S100B and glial fibrillary acidic protein （GFAP） levels and their clinical significance in patients with delayed encephalopathy after acute carbon monoxide poisoning （DEACMP）. Methods By means of enzyme-linked immunno-sorbent assay （ELISA）, the serum SIOOB and GFAP levels from 33 DEACMP patients were assayed, and the condition changes were analyzed with three types of scale ：the activity of daily living scale （ADL） , information-memory-concentration test （IMCT） and Hasegawa＇ s dementia scale（HDS）. The comparison with 32 patients of acute carbon monoxide poisoning without DEACMP was also conducted. Results （ 1 ） The serum S100B（ （0.60 ± 0.21 ） ng/ml） and GFAP（ （226.58 ± 90.05） ng/ml） in DEACMP group at acute stage were significantly higher than those in acute-CO-poisoning group （ （0.50 ± 0. 20） ng/ml, （ 183.04 ± 73.01 ） ng/nd） and those in DEACMP group at convalescent stage （ （ O. 51 -± 0.16） ng/ml, （ 183.25 ± 81.76） ng/ml） （ all P values 〈 0.05 ）. （2） In DEACMP group, the serum SIOOB and GFAP at acute and convalescent stages were significantly correlated （at acute stage： r = 0. 466, P = 0. 006; at convalescent stage： r= 0.365, P=0. 037）. （3）The S100B and GFAP in ineffective DEACMP patients at acute stage were significantly higher than those in the other groups（ all P values 〈 0.05 ）. （4）In DEACMP group, the ADL, HDS and IMCT scores（ （45.21 ± 9.69）, （8.26 ± 6.31 ）, （9.91 ± 7.52） ） at acute stage were significantly dif- ferent from those at convalescent stages （ （ 33.67 ± 13.62 ）, （ 15.91 ± 10.83 ）, （ 19.06 ± 10.37 ） ） （ all P values 〈 0. 01 ）. Conclusion There is secondary brain insult （SBI） in DEACMP; glial activation may play an important role. The S100B and GFAP levels may be associated with the prognosis of DEACMP. Key words: Carbon monoxide poisoning;  Eneephalopathy ;  SIOOB protein;  Glial fibrillary acidic protein