Молекулярно-генетические исследования при фибрилляции предсердий

The purpose of the research: to establish probability and regularities of hereditary of atrial fibrillation (AF) in families, to study connection of primary and secondary AF with polymorphism of a gene B1-adrenoreceptors. 99 probands are presented in this research work with diagnosed AF and their 287 relatives I, II, III degrees of relationship. These families are main group of our research. Inspite of probands families with AF we also examined 82 probands with absence of clinico-electrophisiological displays of the heart diseases and 163 their relatives of I and II degrees of relationship, the second (control) group. In this research the fact of family aggregation of disease in probands families with AF has been established. Heterozygous genotype of a gene of B1-adrenoreceptors (Ser49Gly) can be examined as one of genetic predictors in occurrence of Both primary and secondary AF.