Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation

Objective To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue. Design Case report. Setting Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels. Patient(s) Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure. Intervention(s) Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation. Main Outcome Measure(s) Restoration of ovarian activity. Result(s) Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg. Conclusion(s) Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.