Desregulação na expressão de genes de células progenitoras em infecção por Zika vírus

Objective: To describe the infection by the Zika Virus (VZIK) in progenitor cells and disorder in gene expression from its mediators, non-coding RNAs (ncRNAs). Methods: Observational, cross-sectional of the integrative review type. Articles made available by the platforms: Nature, Medical Literature Analysis and Retrieval System Online (Medline), Science Direct and Digital Repository of the Evandro Chagas Institute (Patua) were selected, based on the search for hypotheses related to changes in the expression of ncRNAs, resulting in physiological changes in progenitor cells from VZIK infection. Results: 72 studies related to the expression of ncRNAs in Zika virus infections were obtained, of which 8 were defined, which portrayed the theme proposal. These established a verisimilitude in the approach of the research object, based on the function of ncRNAs, epigenetic relationship in VZIK infection and activation of immunological mediators, describing the expression of gene products associated with cellular processes corresponding to the host's defense resources and mechanisms viral replication. Final Considerations: Thus, it was observed the importance of studies that provide the experimental technical contribution, on the mechanisms of viral replication, cell tropism, immunogenetic activity, in order to foster the scientific contribution to the control of VZIK.