TRANSFORMATIONS OF COTARNINE CHLORIDE BY THE ACTION OF SILVER ACETYLIDES AND ALKYNES

Three-component reactions of cotarnine chloride with silver acetylides and methyl propiolate or ethynyl methyl ketone in acetonitrile, as well as two-component reactions of 5-phenylethynyl-substituted tetrahydro[1,3]dioxolo[4,5- g ]isoquinoline with alkynes in various solvents were studied. Performing them in 2,2,2-trifluoroethanol as the solvent, 10-phenylethynyl-substituted tetrahydro[1,3]dioxolo[4,5- i ][3]benzazocines were obtained in good yields. Authors: Leonid G. Voskressensky, Alexander A. Titov, Reza Samavati, Tatiana N. Borisova, Elena A. Sorokina, Alexey V. Varlamov