Abstract 651: Protective Role of LRP1 in Second Heart Field-derived Smooth Muscle Cells Against Angiotensin II-induced Thoracic Aortic Aneurysm

Hisashi Sawada,Hideyuki Higashi,Debra L. Rateri,Deborah A. Howatt,Jessica J. Moorleghen,Bradley C Wright,Lang Ho Lee,Sasha A. Singh,Masanori Aikawa,Mark W. Majesky,Alan Daugherty

Abstract 651: Protective Role of LRP1 in Second Heart Field-derived Smooth Muscle Cells Against Angiotensin II-induced Thoracic Aortic Aneurysm

2019

Hisashi Sawada
Hideyuki Higashi
Debra L. Rateri
Deborah A. Howatt
Jessica J. Moorleghen
Bradley C Wright
Lang Ho Lee
Sasha A. Singh
Masanori Aikawa
Mark W. Majesky
Alan Daugherty

Objective: Thoracic aortic aneurysms (TAAs) display a gradient of pathology across the media that is most pronounced in the outer elastin layers of the ascending aorta. The smooth muscle cells (SMC...

Keywords:

smooth muscle
Aortic aneurysm
Biochemistry
LRP1
Diabetes mellitus
Biology
Angiotensin II
Pathology
Elastin
Thoracic aortic aneurysm
Ascending aorta

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